Waa maxay sababta heparin iyo aspirin ay caawin karto
Marka dhiigaagu xinjiroobo, badan oo ka mid ah borotiinka jirkaaga, oo ka mid ah Fiktoor V, si wadajir ah u wada shaqee si ay taasi u dhacdo; Ciladda V Leiden waa isbeddel hidde ah ee F Factor V oo saameeya habka dhiigga-xinjirta iyo ka dhigaya qofka inuu u dhoco xinjiro dhiig.
Baro wax badan oo ku saabsan kala duwanaanshahan hiddaha iyo waxa saameyn ku yeelan kara uurkaaga iyadoo dib loo eegayo.
Nuqulada Farsamada V Leiden Gene
Qofku wuxuu heli karaa nuqul ka mid ah Noocaha V Leiden Factor iyo nuqul caadi ah (macnaheedu waa qofka heterozygous), ama qofku wuxuu yeelan karaa laba nuqul oo ah Caadiyaha V Leiden gen (qofka waa homozygous).
Dhakhaatiirta qaarkood waxay kugula talinayaan heparin dumarka leh dhicin soo noqnoqoshada oo si fiican u tijaabiya Ciladda V Leiden. Weydiiso dhakhtarkaaga haddii ay kugula talineyso heparin, dawo kale ama dawo lagama yaabo oo dhan.
Cadaadiska Protein C
Ciladda V Leiden-ka ayaa sidoo kale la xiriirta xaalad la yidhaahdo caabuqa firfircoon ee C. Protein C waa borotiin kale oo ku lug leh habka xinjirta. Inta badan dadka qaba borotiinka firfircoon ee C ayaa sidoo kale leh Calaamadaha V Leiden kala duwanaansho. Sidaa darted, dumar badan oo aan si khaas ah loogu baarin hargabka V Leiden gen ayaa laga yaabaa in ay ogaadaan in ay yihiin sidayaal ka dib markii ay baaritaan ku sameeyaan borotiinka C.
Tirakoob
Qiyaastii 4% ilaa 7 boqolkiiba dadweynaha waa heterozygous for Factor V Leiden.
Qiyaas ahaan 0.06 Boqolkiiba ilaa 0.25 boqolkiiba dadka ayaa ah kuwa ku haboon ee lagu magacaabo Factor V Leiden. Kooxaha kala duwan ee jinsiyadu waxay leeyihiin heerar kala duwan oo ah isbeddelka Farsamada V Leiden; waxay aad ugu badan tahay dadka waqooyiga Yurub. Kala hadal dhakhtarkaaga haddii aad halis u tahay iyo in kale.
Halista
Ciladda V Leiden macnaheedu waa khatarta sii kordhaysa ee xididada dhiig-xiran ee xididka iyo xinjirta caafimaad ee muhiimka ah.
Daraasadaha qaar ayaa ogaaday in haysashada isku-beddelka "Factor V Leiden" macnaheedu waa khatarta sii kordheysa ee dhicin soo noqnoqoshada , taasoo macquul ah sababtoo ah xinjiro dhiig oo yar oo xannibaya socodka nafaqooyinka ee mandheerta.
Daaweynta
Uurka, dhakhaatiirta qaarkood waxay aaminsan yihiin in la isticmaalo heparin iyo / ama daawo hooseeya ee aspirin si loogu daaweeyo haweenka qaba ciladda V Leiden Factor iyo taariikhda dhicin. Waqtigan xaadirka ah, cilmi-baarayaashu wali waxay baranayaan daaweyntan si ay u xaqiijiyaan in ay dhab ahaantii caawineyso. Xarumaha bacriminta badankood waxay ku talinayaan in bukaanku ay qaataan asbiriin ilmo inta lagu jiro daaweynta kaliya haddii ay qabaan dhibaatooyinka xinjirta.
Xidhiidhka Mucaaradka
Cilmi-baadhayaashu wali waxay baranayaan nooca saxda ah ee xidhiidhka ka dhexeeya Factor V Leiden (iyo kuwa kale ee loo yaqaan thrombophilias ) iyo dhicin-laabashada. Ciladda dhiigga ee xinjirta ee kala duwan ayaa leh heerar kala duwan oo xiriir la leh dhicin, laakiin Fikradda V Leiden waa mid ka mid ah thrombophilias dhaxalka ah ee u muuqda inay kaalin ku leeyihiin keenista dhicinta (ama ugu yaraan khatarta sii kordhaysa) sababta oo ah haweenka isbedelku leeyihiin heer ka sarreeya dhicin ka badan dumarka aan lahayn.
Cilmi-baaris la heli karo waxay soo jeedinaysaa in Farsamada V Leiden ay ka ciyaari karto door-ka dhicitaannada dhacaya 10-kii toddobaad kadib, laakiin waxay u badantahay in ay tahay arrin horay u dhicin.
Dhakhaatiir badan ayaa tijaabiya Factor V Leiden iyada oo qayb ka ah shaqooyinka dhiciska ee soo noqnoqda ee tijaabada ah waxayna kugula talinayaan daaweynta dadka baaritaanka ku habboon.
Ilaha:
Coulam, CB, RS Jeyendran, LA Fishel, iyo R. Roussev, "Isbeddellada hidda-wadeenada badan ee trombofilic ah halkii laga bedeli lahaa isbeddellada gaarka ah ee hiddaha ayaa ah arrimo halis u ah dhicin-laabashada." Somali Journal of Immunology May 2006.
Foka, ZJ, AF Lambropoulos, H. Saravelos, GB Karas, A. Karavida, T. Agorastos, V. Zournatzi, PE Makris, J. Bontis, iyo A. Kotsis, "Isbeddellada V leiden iyo Prothrombin G20210A, ee ma aha methylenetetrahydrofolate reductase C677T, waxay la xiriirtaa dhicin-soo-celinta soo noqnoqda. " Feb 2000.
Jivraj, S., R. Rai, J. Underwood, iyo L. Regan, "Isbeddellada Genetic Trombophilic ee lamaanayaasha ee dhiciska soo noqnoqda." Nuqul Bini'aadanimo May 2006.
Resess V Leiden iyo G20210A isbeddellada 'prothrombin mutations' ayaa ah arrimo halis u ah dhicin hore u soo noqnoqonaysa. '' Cunol, B. Carbonne, A. Robert, F. Coulet, iyo J. Milliez. BJOG Dec 2001.
Jaamacadda Illinois - Urbana / Champaign, "Khayraadka bukaanka: Cilaaqaadka V Leiden." Bogga Khayraadka Dabaysha .
Walker, MC, SE Ferguson, iyo VM Allen, "Heparin oo loogu talagalay haweenka uurka leh ee leh daawooyinka trombophilika ee la helay ama la dhaxlay." Maktabadda Cochrane 21 Jan 2003.