Sababta Saynisyahanno Kufsiirku Shaki Geliyay
Kordhinta diiradda waxaa lagu meeleeyay wax lagu magacaabo MTHFR isbeddelka hidde-qabadka iyo ururradooda iyada oo la socota xaalado caafimaad oo aan caadi ahayn, qaar ka mid ah kuwaas oo si xoogan loo taageersan yahay iyo kuwo kale oo ka mid ah kuwa ugu fiican.
Sannadihii ugu danbeeyay, caqabado badan oo cilmi-baarayaal ah ayaa soo jeediyay in isbeddelku si fiican u sharxi karo sababta dumarka qaarkood ay u soo noqdaan dhicin .
Inkasta oo aragtida ay ka fog tahay dhammaystirnaanta, waxay u keenaysaa arrin ujeeddo ah in genetics ay ka ciyaari karaan dhicis la'aanta aan la garaneyn, haddii ay qayb ahaan ka mid tahay.
Sharaxaadda MTHFR Mutation
Isku-dhafka MTHFR waa miyir-beelka ku jira codka hiddo-galka qofka kaas oo farageliya awoodda jirka ee soo saarida Mitfr enzyme. Macdanta MTHFR, lafteeda, waa kiimikada ay soo saaraan jirka si ay si habboon u kobciyaan folic acid (fitamiin B9) .
Cilad la'aanta ka dhalatay enzme waxay keeni kartaa dhibaatooyin badan. Dhibaatada ugu daran waxay u egtahay in ay ku dhacaan dad ku guulaystay MTHFR labada waalid (dabeecad loo yaqaanno homozygosity), halka kuwa dhaxlaya hal hiddo (heterozygosity) ay yar yihiin, haddii ay jiraan, dhibaatooyin la taaban karo. Haysashada isbadelka MTHFR micnaheedu maahan inaad heli doonto jirro gaar ah; waxaay kordhineysaa halista guud.
Qaar ka mid ah dhibaatooyinka caafimaad ee sida badan ku xiran isku dhafka MTHFR waxaa ka mid ah:
- Homocystinuria, oo ah jirro aan awood u lahayn in ay hirgeliso homocysteine, had iyo jeer waxay keentaa dhibaatooyinka indhaha, xinjirta dhiigga ee aan caadiga ahayn, cilladaha qalafsan, iyo dhibaatooyinka garashada
- Anencephaly , cillad dhalasho oo lagu garto qaybo ka maqan ama aan dhamaystirneyn oo maskaxda ama kafeega
- Spina Bifida, qaabka dhameystiran ee lafta agagaarka xangulaha
- Dhimashada maqalka ee la xidhiidha da'da
Daraasado kale ayaa la xiriiray isbedelka MTHFR ee wadnaha wadnaha, garaacis, dhiig-karka, preeclampsia (cadaadiska dhiigga sareeya waqtiga uurka), glaucoma, xanuunka dhimirka, iyo noocyada kansarka qaarkood. Badanaa daraasaddan ayaa badi isku dhafan. oo leh ururo laga helay qaar ka mid ah, laakiin aan ahayn kuwa kale.
Dhammaantood waxay yiraahdeen, Mitfr muttressin-ka ayaa caadi ahaan caadi ah, iyadoo ku dhawaad kala badh dadwaynaha Maraykanku u badan tahay in ay ugu yaraan heterozygous u noqdaan isbeddel.
MTHFR iyo Khatarta La-Kicinta
Sababtoo ah caddaynta hadda jirta si tartiib tartiib ah loo taageero, waxaa jira saynisyahanno badan oo ka hortagaya fikradda ah in dhicinta iyo MTHFR isku-beddeliddu ay isku xiran yihiin. Kuwa taageeraya hypothesis waxay ku saleynayaan dhacdooyinka sii kordhaya ee dumarka leh noocyo kala duwan oo loo yaqaan MTHFR C677T mutation.
Furaha dooddu waa doorka homocysteine la rumeysan yahay inuu ciyaaro. Homocysteine waa amino acid si dabiici ah u soo saaray by jirka ee caawiya metabolism of vitamin B. Marka uu jiro isbeddelka C677T, homocysteine ma noqon karto mid si wax ku ool ah dib loo soo celiyo isla markaana bilaabmaa inuu ku ururiyo dhiigga. Marka tani dhacdo, waxay u horseedi kartaa xaalad barar ah oo loo yaqaan 'homocysteinemia' taas oo loo yaqaan 'factor factor' oo loo yaqaan 'coronary artery disease'.
Kuwa taageeraya aragti waxay soo jeediyeen in homocysteinemia ay sababi karto sameynta xinjiro dhiig oo yaryar oo xannibaya socodka nafaqada ee mandheerta, asal ahaanna gaajoonaya uurjiifka iyo kicinta ilmo iska soo ridid isdabajoog ah . Waa aragti aad u murugsan, midna maahan wax caddayn ah.
Iyadoo la sheego, dumar badan oo dhicin in dhicin soo noqnoqonayaan waxay tijaabin doonaan isbedelka MTHFR. Sidaa daraadeed, qaar ka mid ah dhakhaatiirta ayaa taageersan isticmaalka daroogada lidka ku ah xinjirowga sida heparin iyo daawada hooseeya ee aspirin si loo yareeyo halista xinjiro dhiig. Qaar kale waxay ku taliyaan qiyaaso badan oo folic acid ah iyo fitamiin B kale, iyaga oo aaminsan in ay siin karaan homocysteine bartilmaameed iyo waddo taas oo looga saarayo jirka.
Inkasta oo aanay jirin caddayn in mid ka mid ah tallaabooyinkani ay yareyn doonto halista dhicin, waxaa sidoo kale jira caddayn yar oo soo jeedinaysa in uu waxyeello u geysan doono.
Erey Aan ka soo Baxay
Dood-doodu waxay sii wadi doontaa inay ka xanaajiso sida saameynta MTHFR isku-beddelka uur-qabka, talobixin ka socota College College of Women's Obstetricians iyo Ginekologist ayaa sheegey in caddaynta hadda jirta ee la xidhiidha arrintu ay tahay "xadid" ama "aan khilaafsaneyn" isla markaana lagula talin in la isticmaalo isticmaalka "genetic MTHFR" falanqaynta ama soonka baaritaanka homocysteine oo qayb ka ah imtixaanka caadiga ah ee dhalmada .
> Ilo:
> Kuleejka American College of Obstetricians iyo Ginekologists. "Akhbaar Tababaraha ACOG No.18: Trombofil-ka-guuraaga ee uurka ku jira ee uurka leh." Obstet Gynecol. 2013; 122 (3): 706-17. DOI: 10.1097 / 01.AOG.0000433981.36184.4e.
> Chen, M .; Yang, X; iyo Lu, M. "Methylenetetrahydrofolat dib u soo noqoshada hiddo-wiiqyada iyo lumista soo noqoshada Shiinaha: dib-u-eegis nidaamsan iyo falanqeyn mala-awaal." Arch Gynecol Obstet . 2016 Feb; 293 (2): 283-90. DOI: 10.1007 / s00404-015-3894-8.