Haddii aad baareyso sababaha dhicin ama khibrad hal mar ama in ka badan oo dhicin, waxaa laga yaabaa inaad ogaatey in dhakhtarradu mar walba sharraxaan sababta ay u dhaceen. Xaqiiqdii, sida laga soo xigtay College College of Obstetrics iyo Gynecology, dhicin-soo-celinta soo noqnoqda waxay leedahay sabab la aqoonsan karo oo keliya 25 ilaa 50 boqolkiiba wakhtiga.
Waxa jira aragtiyo badan oo ku saabsan waxa sababa qaybta kale ee kiisaska dhiciska ah ee soo noqnoqda, laakiin wax yar ayaa la caddeeyey.
Mid ka mid ah aragtida ku jirta qaybta dambe ayaa ah in heerarka sare ee hoormoonka loo yaqaan prolactin laga yaabo in uu gacan ka geysto khasaaraha uurka.
Marka xoog saarista dhiigga sareeya uu farageliyo hawsha ugxan-sidaha haweenka premenopausal, qarsoodi ah estradiol, estrogenka ugu weyn, hoos u dhaca. Astaamaha waxaa ku jira caadooyin aan caadi ahayn ama maqnaansho ah, dhalmo la'aan, calaamadaha menopausal (nalalka kulul iyo qalitaanka siilka) iyo, dhowr sano kadib, osteoporosis. Heerarka prolactin-ka ee sarreeya waxay sidoo kale ka dhigi kartaa dheecaan caanaha naaska.
Waa maxay Prolactin?
Prolactin waa hoormoon hormarsan oo laga soo saaro qanjirka 'pituitary anterior', qanjir xoqan oo ku saleysan maskaxda. Prolactin waxay magaceeda u bixisaa sababtoo ah waxay kaalin weyn ka qaadataa soo saarista waxsoosaarka caanaha ee haweenka nuujinaya. Heerarka prolactin caadi ahaan waxay kordhiyaan inta uurka oo dhan, inkastoo heerarku ay aad ugu kala duwan yihiin dumarka. Heerarka prolactin waxay gaareen heerkooda ugu sarreeya xilliga dhalmada kadibna dib ugu noqdaan ilaa 6 toddobaad kadib dhalmada ka dib (xitaa haddii haweeney naas nuujinayso).
Marka heerarka prolactin ay sare u kacaan, xaalada ayaa lagu calaamadiyay hyperprolactinemia, heerarkan sare waxay faragelin karaan sida ugxan-haweenada haweenku u shaqeeyaan. Tani waxay u horseedi kartaa caadada caadada ah, dhalmo la'aan, iyo mararka qaarkood caanaha laga sii daayo naasaha, inkastoo haweeney aan naas nuujinayn.
Sababta ugu badan ee keenta hyperprolactinemia waa unugyo aan lahayn kansar aan caan ahayn oo loo yaqaan 'adenoma', laakiin xaaladdu waxay sidoo kale ku dhici kartaa dadka qaba hypothyroidism.
Prolactin ayaa sidoo kale lagu siyaadin karaa jawaabta dabeecadaha deegaanka, sida jimicsi culus ama walaaca, iyo dadka qaata daawooyinka saameeya kiimikada maskaxda, dopamine.
Kaalinta Dareemaha
Sababtoo ah caadada iyo wareegga caadada caadiga ah ayaa badanaa joojisa xilliga nuujinta, prolactinku wuxuu u dhaqmaa sida uur-qaadista dabiiciga ah oo ka ilaalisa uurarka dhabarka dambe. Taas oo la yiraahdo, heerarka prolatifin ee jirkaagu waa in aan lagu tiirsanayn sida ka hortagga uurka. U hubso inaad kala hadashid ka-hortagga uur-qaadidda dhalmada ka dib bixiyahaaga daryeelka caafimaadka.
Marka la eego aragtidan si fiican loo aqbalay in heerarka prolactin-ka sareeya ay u nugulaan hawsha ugxumada, haweenka leh heerarka prolactin sare ee isku dayaya inay uuraystaan waxay la kulmi karaan caadada iyo / ama wareegyada wareegga ah ee aan caadi ahayn, taasoo sii adkeyneysa in ay uur yeelato.
Marka ay timaado prolactin iyo dhicin soo noqnoqashada , hase yeeshee, xeerbeegtadu weli way baxayaan. Daraasado dhowr ah ayaa laga heley heerarka kor u kaca ee prolactin ee haweenka leh dhicin soo noqnoqoshada. Maxaa loola jeedaa, si kastaba ha ahaatee, waa muran. Dadka qaarkood waxay dareemaan in prolatifin badani ay sababi karto dhicin, halka kuwo kale ay dareemaan in ay tahay waqti hore si aad u tiraahdo si cad.
Taageerida Sheekada
Marka la eego isdhexgalka hoormoonada kala duwan ee jirka bini'aadamka, waxaa suurtagal ah in isku dheelitir la'aanta keeni karto dhibaatooyin badan.
Maadaama cudurka hyperprolactinemia uu gacan ka geysan karo dhicinta dumarka qaarkood, dhakhaatiirta qaarkood waxay hubin karaan heerka prolivin-ka haweenka waxayna siinayaan daaweyn si loo yareeyo heerka haddii kor loo qaado.
Kiisaska soo noqnoqashada iyo prolactin soo noqnoqda, hal daraasaad oo qadiimi ah ayaa lagu ogaaday heerarka kor u kaca ee prolatifin ee dumarka leh laba ama uur. Marka haweenkaas lagu daaweeyo daawo la yiraahdo bromocriptine (taas oo ka shaqeyneysa heerarka prolactin-ka) uurkooda xigta, waxaa jiray boqolkiiba 85 boqolkiiba nolol ku dhalatay marka la barbar dhigo dumarka aan la daaweynin kuwaas oo lahaa boqolkiiba 52 boqolkiiba nolol nool.
Natiijooyinkaas lama xaqiijin daraasad ballaadhan.
Laakiin, sababtoo ah daaweynta ayaa loo maleynayaa inay tahay mid ammaan ah, dhakhtarrada qaar ayaa tijaabiya oo daweeya prolatifin sareeya marka la tijaabinayo haweenka sababaha keena dhicin laabashada.
In mucaaradka ah ee aragtida
Daraasadaha lagu arkay xiriirka u dhexeeya heerarka sare ee prolactin iyo dhicin ma ahan mid weyn oo ku filan in la noqdo.
Intaa waxa dheer, cilmi-baarayaashu wali si buuxda uma fahmin waxqabadka prolatifin ee jirka, qaar badani waxay dareemayaan in ay tahay waqti hore in la yiraahdo iyo haddii aan la kordhin heerarka prolatifin ee haweenka dhicisoobay waxay leeyihiin isbitaal muhiim ah. Waxyaalaha kale ee asaasiga ah ayaa laga yaabaa inay ku xisaabtamaan heerarka sare ee prolactin ee haweenka leh dhicin.
Halka ay joogsato
Dhakhaatiirta qaarkood waxay si joogta ah u tijaabiyaan prolatifin lammaaneyaasha oo leh dhicin soo noqnoqota oo ay u qoraan daawooyinka, sida bromokriptiyada ama cabergololeedka, si loo yareeyo heerarka prolactin. Daawooyinkani waxay u muuqdaan kuwo badbaado leh in la isticmaalo xilliga uurka waxaana badanaa loo isticmaalaa haweenka qaba infertility-ka ka yimaada hyperprolactinemia. Taas waxaa la yiraahdaa, ma jiraan talooyin rasmi ah oo lagu baaro laguna daweeyo prolatifin dumarka leh dhicin soo noqnoqoshada.
> Ilo:
> Colau, Annamaria, Roger Abs, David Gonzalez-Barcena, Phillipe Chanson, Wolfgang Paulus iyo David Kleinberg, "Natiijooyinka Uurka ee ku-xigeenka daaweynta cabergoolka: natiijooyinka la kordhiyay laga soo qaatay 12-sano oo daraasad lagu ogaanayo." Endocrinology Clinic Jan 2008.
> Hirahara F, Andoh N, Sawai K, Hirabuki T, Uemura T, Minaguchi H. Dhibaatooyinka dheef-shiid kiimikaadka ee soo noqnoqda iyo natiijooyinka tijaabooyinka daaweynta shomaatiriga ee la kala soocay. Fertil Steril . 1998 Aug; 70 (2): 246-52.
> Kaunitz, AM. (Janaayo 2017). Ka-hortagga uur-qaadista dhalmada kadib. In: UpToDate, Schreiber CA (Ed), UpToDate, Waltham, MA.
> Gudida Tababarka ee Bulshada Maraykanka ee Daawada taranka. Qiimeynta iyo daaweynta lumitaanka soo noqoshada ee soo noqnoqota: fikrad guddi ah. Fertil Steril . 2012 Nov; 98 (5): 1103-11.
> Snyder, PJ. (Nofeembar 2016). Sababaha keena hyperprolactinemia. In: UpToDate, Cooper DS (Ed), UpToDate, Waltham, MA.