Heerarka sare ee Homocsysteine iyo Dhibaatooyinka Uurka
Haddii aad soo noqotey dhicin soo noqosho, dhakhtarkaaga ayaa laga yaabaa inuu kugula taliyo inaad hubiso heerka homocysteine ee dhiiggaaga. Waa maxay xaqiiqda waa homocysteine? Sidee u yahay homocysteine oo lala xiriiriyo dhicin iyo dhibaatooyinka kale ee uurka?
Waa maxay Homocysteine?
Homocysteine waa nooca amino acid kaas oo dabiici ah laga helo jirka. Heerarka caadiga ah, ma aha wax halis ah, laakiin heerarka sarreeya ayaa la ogaaday inay la xiriiraan dhicin iyo sidoo kale cudurka wadnaha.
Heerka sare ee Homocysteine
Heer aad u sarreeya ee homocysteine ee dhiiga ku jirta ayaa keena xaalad loo yaqaanno hypercoagulability. Xumaanta ereyga waxaa loola jeedaa xinjirta dhiigga, iyo hypercoagulability macnaheedu waa in dhiigga xinjirku si sahal ah uga fiican yahay.
Marka tani ay dhacdo in xididdada dhiigga, sida halbowleyaasha wadnaha, waxay ka qayb qaadan kartaa xinjirrada xireysa xididdada dhiigga ee keena cudurka halbowlaha wadnaha.
Marka la eego uurka, waxaa loo maleynayaa in xiniinyaha dhiigga yar yar ay xakameyn karaan marinnada dhiigga ee mandheerta, taasoo keenta dhicin.
Khatarta Homocysteine iyo Khatarta Hantida
Noocyo aan sinnayn ah ayaa weli aan la xaqiijin in uu sababo dhicin, laakiin waxaa jira waxyaalo caadi ah oo leh shuruudo kale oo loo yaqaan in ay keenaan dhicin. Hal xaalad, oo loo yaqaan ' antiphospholipid syndrome' , ayaa laga yaabaa in ay keento labada dhicis iyo cudur wadne ah oo isku mid ah.
Dhibaatooyinka kale ee Uurka
Homocysteine-ka sareeya waa halis la xaqiijiyay oo ah dhibaatooyinka kale ee uurka ku jira:
- Hoos-udhaca bacriminta
- Cilladaha korriinka ee dheddigga ah, sida tuubada neerfaha ayaa cillad u eg
- Preeclampsia
- Korniinka korriinka ee intrauterin
Sida dhicin, caddayntu waxay ka soo horjeedaa in heerarka sare ee homocysteine uu sababo dhibaatooyin kale oo uurka ah sida:
- Xayiraadda Goobta
- Cilladda Down syndrome
Isku Khilaafsan Baaritaanka Nidaamka Dheecaan Bini'aadinimada (Hoos u Dhaca)
Haddii dhakhtarkaagu hubiyo heerkaaga homocysteine, waxaa muhiim ah in la ogaado in heerarka caadiga ah ee homocysteine uu yahay mid hagaagsan waqtiga uurka. Si kale haddii loo dhigo, heer la qaato hal dhibic waqti ayaa laga yaabaa inaanay, qasab ahaan, u matalin heerarkaagu inta badan. Waxaa jira dhowr arrimood oo nafaqo iyo hab nololeed oo keenaya maalinba maalin kala duwanaansho. Waxaa intaa dheer, isbeddelka mugga dhiigga ee la xiriira uurka oo lagu daro tiro isbeddel hormoon ah waxay keeni kartaa heerarka inta lagu jiro uurka oo aan khasab ahayn inay matalaan heerarkaaga haddii aanad uur lahayn.
Metabolism iyo Genetics ee heerarka Homocysteine
Haddii aad qabtid heerar badan oo ah homocysteine, genetik-kaaga ayaa noqon kara sabab.
Dadka leh kala duwanaansho ku yeesha hiddo-wadaha MTHFR , gaar ahaan C677T, waxay u badan tahay inay yeeshaan heerar sare oo ah homocysteine. Daraasadaha qaarkood waxay ku heleen xiriir isku-dhafan oo kudhaca maskaxda MTHFR iyo khatarta dhicinta. Qodobka ugu muhiimsan ee ka dambeysa ururku waa in heerarka sare ee homocysteine ee dadka qaba hiddaha 'MTHFR' ay yihiin halis dhicin.
Dhakhaatiirta qaarkood waxay tijaabiyaan hiddaha 'MTHFR' oo ah qayb ka mid ah hawlaha imtixaanka dhasha dhasha .
Qaar kalena waxay dareemaan inay qiimo badan u leeyihiin baaritaanka homocysteine sababtoo ah qof kasta oo aan ku jirin noocyada kala duwan ee MTHFR wuxuu yeelan doonaa heerar sare oo ah amino acid.
Sababaha
Noocyada kala duwan ee MTHFR maaha sabab keliya oo ah homocysteine sare.
Noocyada kala duwan ee MTHFR maaha sabab keliya oo ah homocysteine sare. Jirkaaga wuxuu isticmaalaa nafaqooyinka folic acid , fitamiin B6 iyo fitamiin B12 si loo dheefshiido, ama isticmaalo, homocysteine. Dadka ku filan fitamiinadaas ayaa waxay yeelan karaan heerar sareeya homocysteine.
Xaaladaha caafimaad ee kala duwan iyo daawooyinka ayaa sidoo kale laga yaabaa inay la xiriiraan heerarka sare ee homocysteine.
Khataraha Caafimaadka ee kale
In kastoo doorka saxda ah aan la garaneyn, heerarka sare ee homocysteine ayaa lagu arkay atherosclerosis, weerarada wadnaha, stroke, waallida, cudurka Parkinson, sclerosis badan, iyo suuxdin.
Waxaa loo maleynayaa in heerarka sare ee homocysteine ee dhiigga ku yeelan kara saameyn toos ah ee sunta iyo nidaamka dareemayaasha.
U diyaargaroobida Homocysteine Sare ee Miscarriages Recurrent
Ma jiraan talooyin rasmi ah oo lagu hubinayo heerarka homocysteine ee haweenka leh dhicin soo noqnoqoshada, mana jiraan habab daaweyneed oo guud oo lagu talinayo in lagu karsado heerarka heerkulka homocysteine ee haweenka la ogaaday inay iyaga leeyihiin.
Dhaqaatiirta qaarkood, si kastaba ha ahaatee, waxay tijaabiyaan homocysteine (ama MTHFR-da kala duwanaanshaha) ee haweenka uurka leh ee soo noqnoqonaya loona soo jeediyo daaweyn xitaa haddii aysan jirin talooyin rasmi ah.
Talada caadiga ah ee haweenka heerarka homocysteine ee sareeya waa inay qaataan qiyaaso badan oo folic acid ah iyo fitamiin B si loo hagaajiyo dheef-shiid kiimikaad ee homocysteine. Si kastaba ha ahaatee, talooyinka dhakhtarkaaga, si kastaba ha ahaatee, heerarka sare ee fiitamiinooyinkani ma aha inay sababaan waxyeelooyin oo kaliya laakiin waxay faragalin karaan nuugista fitamiino kale. Kuwa loogu talagalay dadka qaba hiv-ka MTHFR, folic acid supplement ayaa la ogaaday inay yareyso halista dhiciska.
Dhakhaatiir tiro yar ayaa kugula talin kara daaweynta xinjirowga lidka ku ah, sida heparin ama dufanka hooseeya ee aspirin , si looga hortago xinjirowga dhiigga ee sameynta xilliga uurka, laakiin dhaqankani ma aha mid heer caadi ah.
Nasiib wanaag, waxaa jira daraasado socda oo eegaya jawaabaha labadaba su'aalaha ku saabsan doorka sare ee heerarka homocysteine ee uurka iyo habka ugu wanaagsan ee lagu daaweyn karo kuwan haddii ay joogaan.
Ilaha:
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Hekmatdoost, A., Vahid, F., Yari, Z., Sadeghi, M., Eini-Zinab, J., Lakpour, N., iyo S. Arefi. Methyltetrahydrofolate vs Folic Acid Taageeridda Folic Acid ee Kala Duwanaanta Idiopathic Dib U Dhaqso Ixtiraamka Methylenetetrahydrofolate Reductase C677T iyo A1298C Polymorphisms: Maxkamad Kala Duwan oo Xukun ah. QAADO 2015. 10 (12): e0143569.
Levin, B., iyo E. Varga. MTHFR: Wax ka qabashada Dilka Cilmi-baadhista Genetics U Isticmaalidda suugaanta ku saleysan caddaynta. Wargeyska Guud ee La-talinta . 2016. 25 (5): 901-11.
Puri, M., Kaur, L., Walia, G., Mukhopadhhyay, R., Sachdeva, M., Triveldi, S., Ghosh, P., iyo K. Saraswathy. MTHFR C677T Polymorphism, Folate, Fitamiin B12 iyo Homocysteine ee Uurka Uurka: Dhibaato Daraasad Xaaladeed oo ka dhex jirta Haweenka Waqooyiga Hindiya. Joornaalka Daawada uureysiga Dhalmada . 2013. 41 (5): 549-54.
Murphy, M., iyo J. Fernandez-Ballart. Homocysteine ee Uurka Heerka sare ee kiimikada . 2011. 53: 105-37.